2-Fluorine Cinnamic Acid : A Better New Medicine Ingredient

According to the census data makes clear, anorectal disease incidence rate of 59.1%, hemorrhoids, anorectal diseases accounted for all 87.25%, which again the hemorrhoids are the most common, accounting for 52.19% of all anorectal diseases. Men and women may get sick, female incidence rate was 67%, the incidence in males was 53.9%; any age can come on, 20-40, which is more common, and with the growth of age and gradually increase, it is an old saying " nine out of ten person has hemorrhoids ".

Treatment of hemorrhoids, the general idea is: medical treatment for the first, only when medical treatment is not good, hemorrhoids, anal prolapse with severe hematochezia from excessive,can has the operation treatment. In the choice of drugs, medication due to pass through the digestive tract, thelocation of disease, so the adverse reaction is relatively small, is the preferred treatment of hemorrhoids. At present, the market has a lot of kinds of hemorrhoids medication, for its effect or the use of methods, the used people probably have deep feelings.

Recently, people invented a 2 fluoride cinnamic acid as the main raw materials of hemorrhoids drugs for external use. The drug can be wiped, affixed to fumigation and washing, the effect is very good, the use of 2 - fluorine cinnamic acid is a kind of pharmaceutical intermediates, pharmaceutical raw materials, are often used to treat hemorrhoids toxic swelling, traumatic injury, traumatic swelling and pain.

Application of Cinnamic Aldeyde

Name: Cinnamic aldehyde

Synonyms: cinnamaldehyde，β-phenylacrolein , Trans-Cinnamaldehyde

Molecular formula: C9H8O

CAS: 104-55-2

Appearance: Colorless or light yellow liquid

Aroma Unique fragrances

Content (Weather chromatography analysis) ≥ 98%

 

As the constant development of scientific and technological level, the scope of application of cinnamaldehyde become more and more widely, applications continue to extend, in the flavors and fragrances, food additives, pharmaceutical chemicals and feed applications, and other aspects. This article focuses on cinnamic aldehyde in the pharmaceutical and chemical fields.

1. Cinnamaldehyde-- the Application in Medicine

1. Disinfection Antiseptic, especially for Fungi a significant effect.

Escherichia coli, Bacillus subtilis and Staphylococcus aureus bacteria, Staphylococcus albus, Shigella, typhoid and paratyphoid A bacillus, pneumococcus, Aerobacter aerogenes, Proteus, Bacillus anthracis, Salmonella enteritidis, Vibrio cholerae, etc. are inhibition. And against Gram-positive bacteria, a significant bactericidal effect can be used to treat a variety of diseases caused by bacterial infection. Minimum inhibitory concentration (MIC) for the 0.02-0.07ul/ml, right deep pathogenic fungi, MIC for 0.1-0.3ul/ml.

Japanese medical experts recently found cinnamaldehyde a significant effect on the fungi of 22 species of pathogenic fungi conditions Cinnamaldehyde studies have shown that anti-fungal effect: Cinnamic aldehyde is the active anti-fungal substances, mainly through the destruction of fungal cell walls, so that drug infiltration of fungal cells, destruction of organelles and play a bactericidal effect.

2. Antiulcer, strengthening the stomach, intestinal movement.

3. Fat Decomposition.

Cinnamic aldehyde can inhibit the epinephrine and ACTH right of free fatty acids to promote the synthesis of glucose and fat, cinnamic acid, also have such effect, but the role is far greater than cinnamaldehyde cinnamic acid. Thus, drugs can be used for blood glucose control, enhance the performance of glucose-insulin replacement, diabetes control.

4. Antiviral Activity of influenza virus, SV10 virus, a strong inhibitory effect caused by the tumor.

5. Anticancer effect. Inhibit tumors, and have the anti-mutagenic and anti-radiation effect.

6. Expansion of the role of blood vessels and blood pressure. Right adrenal hypertension have blood pressure lowering.

7. Aphrodisiac effect. Treatment Research Center, Chicago, a study showed that cinnamic aldehyde makes a certain effect aphrodisiac for men.

8. Commonly used in external medicine.

Applied in massage fluid, beauty products, promote blood circulation, which can improve water retention, scars on the skin, softening and remove fibroids.

In short, cinnamic aldehyde can be used not only to its own raw material medicine, but also to a variety of external agents, finished drugs, the process can be further in-depth synthesis of a number of powerful drug efficacy.

II. Cinnamaldehyde in the application of chemical

1. Organic chemical synthesis. For the synthesis of α-bromo cinnamic aldehyde, cinnamic acid, cinnamic alcohol, cinnamic nitrile and other products.

2. In the industry, can also be made of color reagent, laboratory reagent.

3. Insecticide, insect repellent, refrigerator deodorant, preservation agent.

Larvae of the Aedes mosquitoes spread yellow fever has a strong killing effect, it will become a new type of insecticide. Cinnamaldehyde is safe, environmentally and smell fragrant, which can be used directly drains (sewers) or vehicle-specific flavor, air fresheners, oxygen generator, refrigerator deodorant, preservation agent.

4. Cinnamic aldehyde can also be applied to oil exploration in the sterilization algicide, acidification inhibitor, to replace the current use of glutaraldehyde and other traditional antiseptic bactericide, which can significantly increase oil production and improve oil quality and reduce mining costs. At present, Hebei Oilfield, Shengli Oilfield have purchased Cinnamaldehyde from us. 

5. Cinnamaldehyde is widely used in anti-corrosion anti-mildew freshness.

6. Cinnamic aldehyde gum sterilization deodorant.
Liangbu Wu reported that the U.S. University of Illinois at Chicago College of Dentistry has an expert report the latest research results, contain cinnamaldehyde composition of natural plant extracts such as the taste of chewing gum can kill bacteria in the mouth , and thus reduce the production of bad breath.

III. The flavors and fragrances 

Modulation as cinnamic aldehyde not only can flavor a variety of flavors, but also on oral play the dual effect sterilization and deodorization. Commonly used in toothpaste, chewing gum, breath fresh oral care agent.

IV. Cinnamaldehyde application in the food industry

Cinnamic aldehyde in foods commonly used in the consumption of spices, fresh anti-corrosion mildew (paper), and a very good seasoning (material) oil, used to improve the taste flavor. Such as: instant noodles, chewing gum, betel nuts and other foodstuffs, as well as bread, cakes, pastries and other baked goods.

Cinnamic aldehyde can be used for anti-mold plastic wrap. Fruit, food preservation and packaging materials.

References:

"Information incense at home and abroad," "China's Pesticide Information Network"

"Komori Medicine Expo," the Oxford English Dictionary

"Baking Industry" Medicine Expo

"Natural Aromatherapy Wikipedia" Japan Medical Abstracts

"China Medical Encyclopedia," University of Chicago, 1997 Annual Report 

Application of Cinnamic Alcohol

English name: Cinnamic Alcohol

Molecular formula: C9H10O

MW: 134.18

CAS: 104-54-1

Content ≥ 98%

Appearance: White to slightly yellow crystal or colorless to pale yellow liquid

 

Uses: Important raw material of medicine. Commonly used in the synthesis of cardiovascular drugs, such as cinnarizine, flunarizine and so on. Right lung caused by a virus can effectively inhibit tumor; a certain concentration of cinnamyl alcohol in mice injected pairs of SV40 virus in the lung tumor inhibition rate was 100%; clinical for leukemia, uterine cancer, ovarian cancer, esophageal cancer and other tumors .

 Important ingredient of Flavor and Fragrance.


It is also one of the important spices, often associated with phenylacetaldehyde sharing, but also can be used as fixed spray modifier. Added to the soap, perfume and chemicals, is the modulation Ocean Narcissus essence, rose essence and other floral fragrance essential raw materials. In the organic chemical synthesis, cinnamyl alcohol can be synthesized cinnamon chloride, acetic acid cinnamon grease.

Specializing in the production of cinnamic acid-cinnamon aldehyde-cinnamon alcohol.

Cinnamic Acid in Propolis and Wine

http://hypcl.tradeindia.com/cinnamic-acid-1090823.html

1. Propolis and Cinnamic Acid

Bee Products include honey, pollen, royal jelly, propolis, beeswax, bee venom, and bee larvae, are the most comprehensive therapeutic Jiapin nutrition and medicine. Bee components can regulate physiological functions, improve immune function, enhance the physical, eliminating fatigue, anti-aging, such as the role of inhibition of tumor and beauty, but also treatment and adjuvant treatment of a variety of ills. 

Since 1910 Kustenmacher identified from propolis cinnamic alcohol and cinnamic acid and subsequently, in the north temperate regions of propolis were identified out of more than 300 kinds of compounds. 

The foreign scholars conduct a large number of experiments show that propolis have killed or inhibited bacteria, fungi, pathogens, nematodes, including Bacillus larvae, Bacillus subtilis, Bacillus thuringiensis, Staphylococcus aureus grapes bacillus, Streptococcus, Streptomyces, baking yeast, E. coli, Salmonella, 112 strains of anaerobic bacteria, Giardia Lambia, Bacteroides, Klebsiella and other bacteria, Candida albicans, Aspergillus niger, Botrytis cinerea molds, bee balloon bacteria, six kinds of fungi such as the human fungal infection, herpes, potato virus, influenza, Newcastle disease and other viruses and worms, etc. (HU Fu-liang, 1998), in which cinnamic acid plays a major role. 

At the same time prove that Propolis (Brazil Bee Propolis and China) as a food ingredient is safe. (Source: "World Agriculture", 2003 12 Authors: Diao Qing-yun Wu Jie Yan Ji Author: Chinese Academy of Agricultural Sciences Institute of Bees) 

Taipei Medical College, Department of Medicine, Professor Lam Chung-Chau, making anti-cancer research, through FITCAnnexin V / PI chromosomes confirmed that propolis can be quite effective in human liver cancer cell apoptosis, leaving liver to obtain a very excellent therapeutic effect. Propolis can generate large and rapid activation of lymphocyte, with quite a significant increase in activity of immune system. 

Taipei Medical College, has also targeted antivirals properties of propolis, research was done, according to Lam Chung-Chau pointed out that the propolis is able to combat influenza infection, mainly because some of these ingredients, such as cinnamic acid, etc., and synthetic analogues of these components can have sense to inhibit influenza virus replication, especially in the infection period of use, the effect is most evident. 

Tissue protein, fat, and pancreatic protein. Cinnamic acid, caffeic acid and other organic acids have anti-bacteria, viruses, fungi functions, and can treat diarrhea and to stabilize the digestive system effects. 

2. Cinnamic Acid and Wine 

Nutrition professor at the University of Barcelona, Spain, Carmen de la Torre pointed out that the 'Red wine contains a tyrosine-derived benzoic acid, cinnamic acid and other antioxidants, after metabolism in the future, contribute to strengthening the body's immune function, prevents oxidation the role of the process and the release of free radicals. 

She also mentioned that drinking a daily amount ranging from 9 to 34 grams of red wine people, the incidence of cardiovascular disease was significantly lower than those who do not drink red wine. From the clinical trial inspections, drinking red wine on the prevention of elderly people suffering from blindness caused by cataracts, as well as Alzheimer dementia, the effect is quite obvious. 

Italian Wine Research Institute research results Research Results [1995 years] 
By ethanol extraction and HPLC analysis confirmed that: sealing plug used for the production of cork in wine there is a variety of phenolic compounds (benzoic acid and cinnamic acid derivatives, vanillin, lilac aldehyde and processing cannabinoids). 

Study of soft wood storage and boiling on the effects of these compounds. In all samples of cinnamic acid and vanillin are a major part of phenolic compounds. After boiling the soft wood, compared with untreated in the original protocatechuic acid, caffeic acid, p-coumaric acid and vanillin concentrations there are significant differences between both. The storage of soft wood and without storage compared to the original protocatechuic acid, 4 - hydroxy benzoic acid, caffeic acid and ferulic acid, significant differences exist. Increase the storage of soft wood that can be extracted out of the content of cinnamic acid. 

Meanwhile, boil to reduce the concentration of the same kinds of phenolic, an increase of vanillin concentration. Storage after the treatment of soft wood to boil the cork can be beneficial to the quality and reduce the potential adverse flavor materials (various cinnamic acid) in the total, while increasing the potential positive effect flavor substances (vanillin) in the total .